Protective Effect of Chemically Characterized Polyphenol-Rich Fraction from Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes on Carbon Tetrachloride-Induced Liver Injury in Mice

Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes (A. europaea) is a medicinal plant widely used in traditional medicines to treat various diseases including hepatic pathogenesis. This study was conducted evaluate the protective effect of chemically characterized polyphenol-rich fraction from A. on carbon tetrachloride-induced liver injury mice. The chemical characterization carried out using HPLC-DAD (high-performance liquid chromatography (HPLC) with diode-array detector (DAD)). Carbon tetrachloride (CCl4) induce injuries mice as described previous works. A at dose 50 mg/Kg its hepatoprotective effect. Next, histopathological and biochemical alterations were investigated. HPLC analysis revealed presence several phenolic compounds: gallic acid, methyl gallate, rutin, ferulic resorcinol. Regarding treated up tetrachloride, no significant nor histological occurred their liver; meanwhile, serious changes noted for recovered only. In conclusion, extract promising source agents against toxic injury.